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刘莉
2010-04-15 00:35   发布范围:公开

 

 

 

 

 

 

刘莉,女,196711月生;现任第四军医大学药理学教研室副教授,硕士生导师,国家中医药管理局中药药理三级实验室副主任19992002,分别获得第四军医大学药理学专业硕士、博士学位,博士论文题目为大黄多糖对结肠炎的治疗作用与组-效关系研究,导师梅其炳教授。1996年,开始从事消化药理和肿瘤药理学研究,建立起中药多糖的分离、纯化等化学研究方法;建立起溃疡性结肠炎、胃肠道损伤修复动力学研究方法,以及UC癌变相关ICR小鼠模型;指导研究生建立起相关细胞分离方法,分子生物学研究平台。发表相关研究论文50余篇SCI收录17篇;负责及参加国家自然科学基金项目3项,均已结题。申请专利6项,2项进入实质审查阶段,2项授权。获得陕西省科技进步一等奖1项。相关论文:

[1]      Liu L, Li YH, Niu Y B, Sun Y, Guo ZJ, Li Q, Li C, Feng J, Cao SS, Mei QB. An apple oligogalactan prevents against inflammation and carcinogenesis by targeting lps/tlr4/nf-κb pathway in a mouse model of colitis-associated colon cancer. Carcinogenesis (2010in press).

[2]      Liu L, Yuan S, Long Y, Guo Z, Sun Y, Li Y, Niu Y, Li C, Mei Q. Immunomodulation of Rheum tanguticum ploysaccharide (RTP) on the immunosupppressive effects of dexamethasone (DEX), on the treatment of colitis in rats induced by 2,4,6-trinitrobenzene sulfonic acid, Int Immunopharmacol 2009; 9: 1568-1577.

[3]      Liu L, Yan S, Sun Y, Long Y, Li Y, Niu Y, Li C, Gan H, Gao S, Mei Q. The possible mechanisms of Fructus Mume pill in the treatment of colitis induced by 2,4,6-trinitrobenzene sulfonic acid in rats. J Ethnopharmacol 2009; 126: 557-565.

[4]      Li YH, Niu YB, Wu HJ, Zhang B, Sun Y, Huang HT, Li Q, Fan L, Liu L(通讯作者),Mei Q. PC-407, a celecoxib derivative, inhibited the growth of colorectal tumor in vitro and in vivo. Cancer Sci 2009; 100: 2451-2458.

[5]      Liu L, Guo ZJ, Lv ZG, Sun Y, Cao W, Zhang R, Liu ZG, Li C, Cao SS, MeiQB. The beneficial effect of Theum tanguticum ploysaccharide on protecting against diarrhea, colonic inflammation and ulceration in rats with TNBS-induced colitis: The role of macrophage mannose receptor in inflammation and immune response. Int Immunopharma 2008; 8: 1481-1492.

[6]      Wang QW, Liu XY, Liu L, Fen J, Li YH, Guo ZJ, Mei QB. Synthesis and evaluation of the 5-fluorouracil-pectin conjugate targeted at the colon. Med Chem Res 2007; 16: 370-379.

[7]      Cao W, Li XQ, Liu L, Yang TH, Li C, Fan HT, Jia M, Lv z, Mei Q. Structure analysis of an anti-tumor polysaccharide from Angelica sinensis (Oliv.) Diels. Carbiohydrate Polymers 2006; 66: 149-59.

[8]      Cao W, Li XQ, Liu L, Wang M, Fan HT, Li C, Lv Z, Wang X, MeiQ. Structural analysis of water-soluble glucans from the root of Angelica sinensis (Oliv.) Diels Carbohydr Res 2006; 341: 1870-1877.

[9]      Liu L, Mei QB, Wang ZP, Zhou YM, Long Y. The effects of Theum tanguticum polysaccharide on polarization of Th1 and Th2 cells in TNBS-induced colitis in murine. IJBS 2005; 1: 23-32.

[10]   梅其炳,刘莉,周四元,杨铁虹,商澎、王志鹏、曹蔚、张蓉、刘琳娜、刘新友、杨兴斌. 当归多糖和大黄多糖的应用基础研究. 2007,陕西省科学技术一等奖,No 07-1-21R2.

 

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