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马雪
2010-04-13 19:34   发布范围:公开

 

 

 

马雪女,第四军医大学药学系药理学教研室助教。2003年毕业于第四军医大学临床医学专业,获医学学士学位,2004年至2010年攻读药理学专业硕博连读研究生博士学位,2010年获药理学专业医学博士学位。主要从事GLP-1相关的新药研究及分子药理的研究,作为主要研究人员参与了国家重大新药创制科技专项 2009ZX09103-663)《新型糖尿病治疗药物 Pro-rhGLP-1的研究》、陕西省国际合作项目基金(05D018)《新型抗糖尿病药物-前胰高血糖素样肽-1的研究》及西安市重大专项计划项目(ZX06015)《新型抗糖尿病药物-前胰高血糖素样肽-1临床前研究》等项目研究,并先后参与了5项国家自然科学基金。论文《重组人胰高血糖样肽前药的表达、纯化及生物活性分析》作为2008年中国药学会学术年会老年药学分会场报告并获优秀论文二等奖。

代表性论文:

1.         Ma X, Hui H, Liu Z, He G, Hu J, Meng J, Guan L, Lou X. Poly-GLP-1, a novel long-lasting glucagon-like peptide-1 polymer, ameliorates hyperglycaemia by improving insulin sensitivity and increasing pancreatic beta-cell proliferation. Diabetes Obes Metab. 2009; 11:953-65.

2.         Ma X, Wu Y, Li M, Meng J, Luo X. The long-acting glucagon-like peptide-1 prodrug, Pro-GLP-1, ameliorates glycemia and stimulates insulin secretion in mice. Acta Pharmacol Sin. 2006; 27(Suppl 1): 300.

3.         He G, Ma X, Lu J, Meng J, Chen Y, Jia M, Luo X. Alpha2 adrenoceptors modulate histamine release from sympathetic nerves in the guinea pig vas deferens. Neuropharmacology. 2009;57(5-6):506-10.

4.         Meng J, Ma X, Li M, Jia M, Luo X. Histamine H(4) receptors regulate ACTH release in AtT-20 cells. Eur J Pharmacol. 2008;587(1-3):336-8.

5.         He G, Hu J, Ma X, Li M, Wang H, Meng J, Jia M, Luo X. Sympathetic histamine exerts different pre- and post-synaptic functions according to the frequencies of nerve stimulation in guinea pig vas deferens. J Neurochem. 2008;106(4):1710-9.

6.         Li M, Hu J, Ma X, Luo X et al. Evidence for histamine as a neurotransmitter in the cardiac sympathetic nervous system. Am J Physiol Heart Circ Physiol, 2006; 291:45-51.

7.         Liu Z, Zhang R, Li C, Ma X, Liu L, Wang J, Mei Q. The osteoprotective effect of Radix Dipsaci extract in ovariectomized rats. J Ethnopharmacol. 2009;123(1):74-81.

8.         Wu Y, Wang H, Zhang J, Ma X, Meng J, Li Y, Hou Z, Luo X. Adenosine deaminase that acts on RNA 1 p150 in alveolar macrophage is involved in LPS-induced lung injury. Shock. 2009;31(4):410-15.

9.         Wang H, Hou Z, Wu Y, Ma X, Luo X. p150 ADAR1 isoform involved in maintenance of HeLa cell proliferation. BMC cancer. 2006; 6: 282.

10.     Luo X, Li M, Hu J, Ma X. Evidence for histamine as a neurotransmitter in the sympathetic nervous system. Acta Pharmacol Sin. 2006; 27(Suppl 1): 148.

11.     Zhu X, Xiong L, Wang Q, Liu Z, Ma X, Zhu Z, Hu S, Gong G, Chen S. Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats. Neurosci Lett. 2009;449(1):24-7.

12.     Li M, Hu J, Chen T, Meng J, Ma X, Li J, Jia M, Luo X. Histamine in Macaca mulatto monkey cardiac sympathetic nerve system: a morphological and functional assessment. Auton Neurosci. 2007; 137(1-2):37-43.

13.     Meng J, Wang H, Hou Z, Chen T, Fu J, Ma X, He G, Xue X, Jia M, Luo X. Novel anion liposome-encapsulated antisense oligonucleotide restores susceptibility of methicillin-resistant Staphylococcus aureus and rescues mice from lethal sepsis by targeting mecA. Antimicrob Agents Chemother. 2009;53(7):2871-8.

14.     Hu J, Chen T, Li M, He G, Meng J, Ma X, Wu Y, Jia M, Luo X. Wide distribution and subcellular localization of histamine in sympathetic nervous systems of different species. Neurosci Res. 2007; 59(2):231-6.

15.     马雪惠宏襄, 周颖, 何功浩, 孟静茹, 贾敏, 罗晓星. 重组人胰高血糖素样肽前药的表达、纯化及生物活性分析. 中国药学杂志, 2008, 10 (2): 31-34.

16.    马雪 惠宏襄, 刘振国, 吴玉梅, 孟嘉, 罗晓星. 前胰高血糖素样肽-1对非糖尿病小鼠降糖作用的实验研究. 中国临床药理学与治疗学, 2007, 12 (1): 28-31.

 

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